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2015 ; 11
(9
): e1005099
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Microbial Regulation of p53 Tumor Suppressor
#MMPMID26379246
Zaika AI
; Wei J
; Noto JM
; Peek RM
PLoS Pathog
2015[Sep]; 11
(9
): e1005099
PMID26379246
show ga
p53 tumor suppressor has been identified as a protein interacting with the large
T antigen produced by simian vacuolating virus 40 (SV40). Subsequent research on
p53 inhibition by SV40 and other tumor viruses has not only helped to gain a
better understanding of viral biology, but also shaped our knowledge of human
tumorigenesis. Recent studies have found, however, that inhibition of p53 is not
strictly in the realm of viruses. Some bacterial pathogens also actively inhibit
p53 protein and induce its degradation, resulting in alteration of cellular
stress responses. This phenomenon was initially characterized in gastric
epithelial cells infected with Helicobacter pylori, a bacterial pathogen that
commonly infects the human stomach and is strongly linked to gastric cancer.
Besides H. pylori, a number of other bacterial species were recently discovered
to inhibit p53. These findings provide novel insights into host-bacteria
interactions and tumorigenesis associated with bacterial infections.
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