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2015 ; 27
(2
): 219-26
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MicroRNAs in the pathogenesis of cystic kidney disease
#MMPMID25490692
Phua YL
; Ho J
Curr Opin Pediatr
2015[Apr]; 27
(2
): 219-26
PMID25490692
show ga
PURPOSE OF REVIEW: Cystic kidney diseases are common renal disorders
characterized by the formation of fluid-filled epithelial cysts in the kidneys.
The progressive growth and expansion of the renal cysts replace existing renal
tissue within the renal parenchyma, leading to reduced renal function. While
several genes have been identified in association with inherited causes of cystic
kidney disease, the molecular mechanisms that regulate these genes in the context
of post-transcriptional regulation are still poorly understood. There is
increasing evidence that microRNA (miRNA) dysregulation is associated with the
pathogenesis of cystic kidney disease. RECENT FINDINGS: In this review, recent
studies that implicate dysregulation of miRNA expression in cystogenesis will be
discussed. The relationship of specific miRNAs, such as the miR-17?92 cluster and
cystic kidney disease, miR-92a and von Hippel-Lindau syndrome, and alterations in
LIN28-LET7 expression in Wilms tumor will be explored. SUMMARY: At present, there
are no specific treatments available for patients with cystic kidney disease.
Understanding and identifying specific miRNAs involved in the pathogenesis of
these disorders may have the potential to lead to the development of novel
therapies and biomarkers.
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