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2014 ; 11
(8
): 1277-85
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MicroRNAs in respiratory disease A clinician s overview
#MMPMID25172373
Brown D
; Rahman M
; Nana-Sinkam SP
Ann Am Thorac Soc
2014[Oct]; 11
(8
): 1277-85
PMID25172373
show ga
Since their initial discovery in the early 1990s, microRNAs have now become the
focus of a multitude of lines of investigation ranging from basic biology to
translational applications in the clinic. Previously believed to be of no
biological relevance, microRNAs regulate processes fundamental to human health
and disease. In diseases of the lung, microRNAs have been implicated in
developmental programming, as drivers of disease, potential therapeutic targets,
and clinical biomarkers; however, several obstacles must be overcome for us to
fully realize their potential therapeutic use. Here, we provide for the clinician
an overview of microRNA biology in selected diseases of the lung with a focus on
their potential clinical application.