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2014 ; 2
(3
): 133-142
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MicroRNAs in Cholangiopathies
#MMPMID25097819
O'Hara SP
; Gradilone SA
; Masyuk TV
; Tabibian JH
; LaRusso NF
Curr Pathobiol Rep
2014[Sep]; 2
(3
): 133-142
PMID25097819
show ga
Cholangiocytes, the cells lining bile ducts, comprise a small fraction of the
total cellular component of the liver, yet perform the essential role of bile
modification and transport of biliary and blood constituents. Cholangiopathies
are a diverse group of biliary disorders with the cholangiocyte as the target
cell; the etiopathogenesis of most cholangiopathies remains obscure. MicroRNAs
are small non-coding RNAs that post-transcriptionally regulate gene expression.
These small RNAs may not only be involved in the etiopathogenesis of disease, but
are showing promise as diagnostic and prognostic tools. In this brief review, we
summarize recent work regarding the role of microRNAs in the etiopathogenesis of
several cholangiopathies, and discuss their utility as prognostic and diagnostic
tools.