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2015 ; 10
(ä): 95-102
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MicroRNA-155 and Its Role in Malignant Hematopoiesis
#MMPMID26523117
Ranganath P
Biomark Insights
2015[]; 10
(ä): 95-102
PMID26523117
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MicroRNA-155 (miR-155) is a multifunctional molecule involved in both normal and
malignant hematopoiesis. It has been found to be involved in the pathogenesis of
many different hematological malignancies with either an oncogenic or a
tumor-repressor effect, depending on the nature of the cell and the type of
malignancy. In particular, it has been strongly implicated in the causation of
diffuse large B-cell lymphomas. This review focuses on the molecular interactions
of miR-155, its oncogenic mechanisms, and its potential as an effective
therapeutic target for the associated malignancies.