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2014 ; 28
(ä): 6-11
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MicroRNA regulation of the germinal center response
#MMPMID24530656
Baumjohann D
; Ansel KM
Curr Opin Immunol
2014[Jun]; 28
(ä): 6-11
PMID24530656
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The generation of germinal centers (GCs) is a hallmark feature of the adaptive
immune response, resulting in the production of high-affinity antibodies that
neutralize pathogens and confer protection upon reinfection. The GC response
requires interactions between different immune cell types, and the coordination
of complex and dynamic gene expression networks within these cells. Here we
provide deeper insights into how microRNAs, small endogenously expressed RNAs,
regulate the cellular processes involved in the differentiation and function of T
follicular helper cells and germinal center B cells, the two main players of the
T cell-dependent humoral immune response.