Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/1471-2164-15-333 http://scihub22266oqcxt.onion/10.1186/1471-2164-15-333 C4035064!4035064 !24885635     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24885635 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       BMC+Genomics 2014 ; 15 (1 ): 333 Nephropedia Template TP {{tp|p=24885635 |t=2014. MicroRNA profiling of rats with ochratoxin A nephrotoxicity |pdf=|usr=}}{{24885635 }} gab.com Text MicroRNA profiling of rats with ochratoxin A nephrotoxicity JO: BMC Genomics http://www.kidney.de/pget.php?&tw=1&pmid=24885635 #FOAvip BACKGROUND: Nephrotoxicity is the most prominent one among the various toxicities of ochratoxin A (OTA). MicroRNAs (miRNAs) are small non-coding RNAs that have an impact on a wide range of biological processes by regulating gene expression at post-transcriptional level or protein systhesis level. The objective of this study is to analyze miRNA profiling in the kidneys of rats gavaged with OTA. RESULTS: To profile miRNAs in the kidneys of rats with OTA nephrotoxicity, high-throughput sequencing and bioinformatics approaches were applied to analyze the miRNAs in the kidney of rats following OTA treatment. A total of 409 known miRNAs and 8 novel miRNAs were identified in the kidney and the levels of the novel miRNAs were varied in response to different doses of OTA. Expression of miR-129, miR-130a, miR-130b, miR-141, miR-218b and miR-3588 were uniquely suppressed in mid dose but then elevated in high dose, with opposite expression to their target genes. The expression pattern was closely related with the "MAPK signaling pathway". Dicer1 and Drosha were significantly suppressed, indicating an impairment of miRNA biogenesis in response to OTA. CONCLUSIONS: The abrogation of miRNA maturation process suggests a new target of OTA toxicity. Moreover, the identification of the differentially expressed miRNAs provides us a molecular insight into the nephrtoxicity of OTA. Twit Text FOAVip MicroRNA profiling of rats with ochratoxin A nephrotoxicity ????BMC Genomics http://www.kidney.de/pget.php?&tw=1&pmid=24885635 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24885635 #FOAvip English Wikipedia <ref>{{Cite pmid|24885635 }}</ref> MicroRNA profiling of rats with ochratoxin A nephrotoxicity #MMPMID24885635 Dai Q ; Zhao J ; Qi X ; Xu W ; He X ; Guo M ; Dweep H ; Cheng WH ; Luo Y ; Xia K ; Gretz N ; Huang K BMC Genomics 2014[May]; 15 (1 ): 333 PMID24885635 show ga BACKGROUND: Nephrotoxicity is the most prominent one among the various toxicities of ochratoxin A (OTA). MicroRNAs (miRNAs) are small non-coding RNAs that have an impact on a wide range of biological processes by regulating gene expression at post-transcriptional level or protein systhesis level. The objective of this study is to analyze miRNA profiling in the kidneys of rats gavaged with OTA. RESULTS: To profile miRNAs in the kidneys of rats with OTA nephrotoxicity, high-throughput sequencing and bioinformatics approaches were applied to analyze the miRNAs in the kidney of rats following OTA treatment. A total of 409 known miRNAs and 8 novel miRNAs were identified in the kidney and the levels of the novel miRNAs were varied in response to different doses of OTA. Expression of miR-129, miR-130a, miR-130b, miR-141, miR-218b and miR-3588 were uniquely suppressed in mid dose but then elevated in high dose, with opposite expression to their target genes. The expression pattern was closely related with the "MAPK signaling pathway". Dicer1 and Drosha were significantly suppressed, indicating an impairment of miRNA biogenesis in response to OTA. CONCLUSIONS: The abrogation of miRNA maturation process suggests a new target of OTA toxicity. Moreover, the identification of the differentially expressed miRNAs provides us a molecular insight into the nephrtoxicity of OTA. |*Gene Expression Profiling [MESH] |Animals [MESH] |High-Throughput Nucleotide Sequencing [MESH] |Kidney/*drug effects/metabolism [MESH] |MAP Kinase Signaling System [MESH] |MicroRNAs/*genetics [MESH] |Ochratoxins/*toxicity [MESH] |Polymerase Chain Reaction [MESH]MicroRNA profiling of rats with ochratoxin A nephrotoxicity (epmc).pdf DeepDyve Pubget Overpricing