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2017 ; 6
(3
): ä Nephropedia Template TP
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MicroRNA Signaling in Embryo Development
#MMPMID28906477
Gross N
; Kropp J
; Khatib H
Biology (Basel)
2017[Sep]; 6
(3
): ä PMID28906477
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Expression of microRNAs (miRNAs) is essential for embryonic development and
serves important roles in gametogenesis. miRNAs are secreted into the
extracellular environment by the embryo during the preimplantation stage of
development. Several cell types secrete miRNAs into biological fluids in the
extracellular environment. These fluid-derived miRNAs have been shown to
circulate the body. Stable transport is dependent on proper packaging of the
miRNAs into extracellular vesicles (EVs), including exosomes. These vesicles,
which also contain RNA, DNA and proteins, are on the forefront of research on
cell-to-cell communication. Interestingly, EVs have been identified in many
reproductive fluids, such as uterine fluid, where their miRNA content is proposed
to serve as a mechanism of crosstalk between the mother and conceptus. Here, we
review the role of miRNAs in molecular signaling and discuss their transport
during early embryo development and implantation.
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