Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26371044
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cancers+(Basel)
2015 ; 7
(3
): 1806-14
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
MicroRNA Polymorphisms in Cancer: A Literature Analysis
#MMPMID26371044
Pipan V
; Zorc M
; Kunej T
Cancers (Basel)
2015[Sep]; 7
(3
): 1806-14
PMID26371044
show ga
Single nucleotide polymorphisms (SNPs) located in microRNA (miRNA) genes
(miR-SNPs) have attracted increasing attention in recent years due to their
involvement in the development of various types of cancer. Therefore, a
systematic review on this topic was needed. From 55 scientific publications we
collected 20 SNPs, which are located within 18 miRNA encoding genes and have been
associated with 16 types of cancer. Among 20 miRNA gene polymorphisms 13 are
located within the premature miRNA region, five within mature, and two within
mature seed miRNA region. We graphically visualized a network of miRNA-cancer
associations which revealed miRNA genes and cancer types with the highest number
of connections. Our study showed that, despite a large number of variations
currently known to be located within miRNA genes in humans, most of them have not
yet been tested for association with cancer. MicroRNA SNPs collected in this
study represent only 0.43% of known miRNA gene variations (20/4687). Results of
the present study will be useful to researchers investigating the clinical use of
miRNAs, such as the roles of miRNAs as diagnostic markers and therapeutic
targets.
free
free
free
