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2016 ; 17
(4
): 564
Nephropedia Template TP
gab.com Text
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MiRTargetLink--miRNAs, Genes and Interaction Networks
#MMPMID27089332
Hamberg M
; Backes C
; Fehlmann T
; Hart M
; Meder B
; Meese E
; Keller A
Int J Mol Sci
2016[Apr]; 17
(4
): 564
PMID27089332
show ga
Information on miRNA targeting genes is growing rapidly. For high-throughput
experiments, but also for targeted analyses of few genes or miRNAs, easy analysis
with concise representation of results facilitates the work of life scientists.
We developed miRTargetLink, a tool for automating respective analysis procedures
that are frequently applied. Input of the web-based solution is either a single
gene or single miRNA, but also sets of genes or miRNAs, can be entered. Validated
and predicted targets are extracted from databases and an interaction network is
presented. Users can select whether predicted targets, experimentally validated
targets with strong or weak evidence, or combinations of those are considered.
Central genes or miRNAs are highlighted and users can navigate through the
network interactively. To discover the most relevant biochemical processes
influenced by the target network, gene set analysis and miRNA set analysis are
integrated. As a showcase for miRTargetLink, we analyze targets of five cardiac
miRNAs. miRTargetLink is freely available without restrictions at
www.ccb.uni-saarland.de/mirtargetlink.