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2015 ; 8
(ä): 68
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MiRNA-based therapeutic intervention of cancer
#MMPMID26062952
Naidu S
; Magee P
; Garofalo M
J Hematol Oncol
2015[Jun]; 8
(ä): 68
PMID26062952
show ga
MicroRNAs (miRNAs) are important modulators of eukaryotic gene expression. By
targeting protein coding transcripts, miRNAs influence the cellular transcriptome
and proteome, thus helping to determine cell fate. MiRNAs have emerged as crucial
molecules in cancer research, in which recent studies have linked erratic
expression of miRNAs to carcinogenesis and have provided solid evidence for their
potential in cancer therapy. This review briefly summarises the recent knowledge
on the involvement of miRNAs in tumourigenesis and reviews current studies on the
therapeutic strategies and advances in the delivery of miRNAs.