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10.18632/oncotarget.11799 http://scihub22266oqcxt.onion/10.18632/oncotarget.11799 C5325428!5325428 !27602768     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27602768 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27602768 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (39 ): 64100-64108 Nephropedia Template TP {{tp|p=27602768 |t=2016. MiR-19b suppresses PTPRG to promote breast tumorigenesis |pdf=|usr=}}{{27602768 }} gab.com Text MiR-19b suppresses PTPRG to promote breast tumorigenesis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27602768 #FOAvip Protein tyrosine phosphatase receptor type G (PTPRG) is an important tumor suppressor gene in multiple human cancers. In this study, we found that PTPRG protein levels were downregulated in breast cancer tissues while the mRNA levels varied irregularly, implying a post-transcriptional mechanism was involved. Because microRNAs are powerful post-transcriptional regulators of gene expression, we used bioinformatics analysis to search for microRNAs that potentially targets PTPRG in the setting of breast cancer. We identified two specific binding sites for miR-19b in the 3'-untranslated region of PTPRG. We further identified an inverse correlation between miR-19b and PTPRG protein levels, but not mRNA levels, in human breast cancer tissues. By overexpressing or knocking down miR-19b in MCF-7 cells and MDA-231 cells, we experimentally confirmed that miR-19b directly suppresses PTPRG expression. Furthermore, we determined that the inhibition of PTPRG by miR-19b leads to increased proliferation, stimulated cell migration and reduced apoptosis. Taken together, our findings provide the first evidence that miR-19b inhibits PTPRG expression to promote tumorigenesis in human breast cancer. Twit Text FOAVip MiR-19b suppresses PTPRG to promote breast tumorigenesis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27602768 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27602768 #FOAvip English Wikipedia <ref>{{Cite pmid|27602768 }}</ref> MiR-19b suppresses PTPRG to promote breast tumorigenesis #MMPMID27602768 Liu M ; Yang R ; Urrehman U ; Ye C ; Yan X ; Cui S ; Hong Y ; Gu Y ; Liu Y ; Zhao C ; Yan L ; Zhang CY ; Liang H ; Chen X Oncotarget 2016[Sep]; 7 (39 ): 64100-64108 PMID27602768 show ga Protein tyrosine phosphatase receptor type G (PTPRG) is an important tumor suppressor gene in multiple human cancers. In this study, we found that PTPRG protein levels were downregulated in breast cancer tissues while the mRNA levels varied irregularly, implying a post-transcriptional mechanism was involved. Because microRNAs are powerful post-transcriptional regulators of gene expression, we used bioinformatics analysis to search for microRNAs that potentially targets PTPRG in the setting of breast cancer. We identified two specific binding sites for miR-19b in the 3'-untranslated region of PTPRG. We further identified an inverse correlation between miR-19b and PTPRG protein levels, but not mRNA levels, in human breast cancer tissues. By overexpressing or knocking down miR-19b in MCF-7 cells and MDA-231 cells, we experimentally confirmed that miR-19b directly suppresses PTPRG expression. Furthermore, we determined that the inhibition of PTPRG by miR-19b leads to increased proliferation, stimulated cell migration and reduced apoptosis. Taken together, our findings provide the first evidence that miR-19b inhibits PTPRG expression to promote tumorigenesis in human breast cancer. |3' Untranslated Regions [MESH] |Apoptosis [MESH] |Binding Sites [MESH] |Breast Neoplasms/drug therapy/*genetics/metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Movement [MESH] |Cell Proliferation/genetics [MESH] |Cell Survival [MESH] |Cell Transformation, Neoplastic/genetics [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |MCF-7 Cells [MESH] |MicroRNAs/*genetics [MESH] |RNA, Messenger/metabolism [MESH] |RNA, Small Interfering/metabolism [MESH]MiR-19b suppresses PTPRG to promote breast tumorigenesis (epmc).pdf DeepDyve Pubget Overpricing