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10.1038/aps.2016.9 http://scihub22266oqcxt.onion/10.1038/aps.2016.9 C4857552!4857552 !27063217     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27063217 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Acta+Pharmacol+Sin 2016 ; 37 (5 ): 571-9 Nephropedia Template TP {{tp|p=27063217 |t=2016. Metrnl: a secreted protein with new emerging functions |pdf=|usr=}}{{27063217 }} gab.com Text Metrnl: a secreted protein with new emerging functions JO: Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=27063217 #FOAvip Secreted proteins play critical roles in physiological and pathological processes and can be used as biomarkers and therapies for aging and disease. Metrnl is a novel secreted protein homologous to the neurotrophin Metrn. But this protein, unlike Metrn that is mainly expressed in the brain, shows a relatively wider distribution in the body with high levels of expression in white adipose tissue and barrier tissues. This protein plays important roles in neural development, white adipose browning and insulin sensitization. Based on its expression and distinct functions, this protein is also called Cometin, Subfatin and Interleukin 39, which refer to its neurotrophic effect, adipokine function and the possible action as a cytokine, respectively. The spectrum of Metrnl functions remains to be determined, and the mechanisms of Metrnl action need to be elucidated. In this review, we focus on the discovery, structural characteristics, expression pattern and physiological functions of Metrnl, which will assist in developing this protein as a new therapeutic target or agent. Twit Text FOAVip Metrnl: a secreted protein with new emerging functions ????Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=27063217 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27063217 #FOAvip English Wikipedia <ref>{{Cite pmid|27063217 }}</ref> Metrnl: a secreted protein with new emerging functions #MMPMID27063217 Zheng SL ; Li ZY ; Song J ; Liu JM ; Miao CY Acta Pharmacol Sin 2016[May]; 37 (5 ): 571-9 PMID27063217 show ga Secreted proteins play critical roles in physiological and pathological processes and can be used as biomarkers and therapies for aging and disease. Metrnl is a novel secreted protein homologous to the neurotrophin Metrn. But this protein, unlike Metrn that is mainly expressed in the brain, shows a relatively wider distribution in the body with high levels of expression in white adipose tissue and barrier tissues. This protein plays important roles in neural development, white adipose browning and insulin sensitization. Based on its expression and distinct functions, this protein is also called Cometin, Subfatin and Interleukin 39, which refer to its neurotrophic effect, adipokine function and the possible action as a cytokine, respectively. The spectrum of Metrnl functions remains to be determined, and the mechanisms of Metrnl action need to be elucidated. In this review, we focus on the discovery, structural characteristics, expression pattern and physiological functions of Metrnl, which will assist in developing this protein as a new therapeutic target or agent. |Adipokines/genetics/*metabolism [MESH] |Adipose Tissue, Brown/metabolism [MESH] |Adipose Tissue, White/metabolism [MESH] |Animals [MESH] |Humans [MESH] |Insulin Resistance [MESH] |Intercellular Signaling Peptides and Proteins/genetics/metabolism [MESH] |Nerve Growth Factors/genetics/*metabolism [MESH] |Nerve Tissue Proteins/genetics/metabolism [MESH]Metrnl: a secreted protein with new emerging functions (epmc).pdf DeepDyve Pubget Overpricing