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10.1016/j.ymeth.2015.01.003 http://scihub22266oqcxt.onion/10.1016/j.ymeth.2015.01.003 C4355229!4355229 !25595300     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25595300 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Methods 2015 ; 75 (ä): 133-40 Nephropedia Template TP {{tp|p=25595300 |t=2015. Methods to study chaperone-mediated autophagy |pdf=|usr=}}{{25595300 }} gab.com Text Methods to study chaperone-mediated autophagy JO: Methods http://www.kidney.de/pget.php?&tw=1&pmid=25595300 #FOAvip Chaperone-mediated autophagy (CMA) is a multistep process that involves selective degradation and digestion of a pool of soluble cytosolic proteins in lysosomes. Cytosolic substrates are selectively identified and targeted by chaperones to lysosomes where they are subsequently translocated into the organelle lumen through a dedicated CMA-associated lysosomal membrane receptor/translocation complex. CMA contributes to maintaining a functional proteome, through elimination of altered proteins, and participates in the cellular energetic balance through amino acid recycling. Defective or dysfunctional CMA has been associated with human pathologies such as neurodegeneration, cancer, immunodeficiency or diabetes, increasing the overall interest in methods to monitor this selective autophagic pathway. Here, we describe approaches used to study CMA in different experimental models. Twit Text FOAVip Methods to study chaperone-mediated autophagy ????Methods http://www.kidney.de/pget.php?&tw=1&pmid=25595300 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25595300 #FOAvip English Wikipedia <ref>{{Cite pmid|25595300 }}</ref> Methods to study chaperone-mediated autophagy #MMPMID25595300 Patel B ; Cuervo AM Methods 2015[Mar]; 75 (ä): 133-40 PMID25595300 show ga Chaperone-mediated autophagy (CMA) is a multistep process that involves selective degradation and digestion of a pool of soluble cytosolic proteins in lysosomes. Cytosolic substrates are selectively identified and targeted by chaperones to lysosomes where they are subsequently translocated into the organelle lumen through a dedicated CMA-associated lysosomal membrane receptor/translocation complex. CMA contributes to maintaining a functional proteome, through elimination of altered proteins, and participates in the cellular energetic balance through amino acid recycling. Defective or dysfunctional CMA has been associated with human pathologies such as neurodegeneration, cancer, immunodeficiency or diabetes, increasing the overall interest in methods to monitor this selective autophagic pathway. Here, we describe approaches used to study CMA in different experimental models. |Autophagy/*genetics [MESH] |Humans [MESH] |Lysosomes/genetics/metabolism [MESH] |Molecular Biology/*methods [MESH] |Molecular Chaperones/*genetics/metabolism [MESH]Methods to study chaperone-mediated autophagy (epmc).pdf DeepDyve Pubget Overpricing