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2017 ; 10
(ä): 284
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Methods Used to Evaluate Pain Behaviors in Rodents
#MMPMID28932184
Deuis JR
; Dvorakova LS
; Vetter I
Front Mol Neurosci
2017[]; 10
(ä): 284
PMID28932184
show ga
Rodents are commonly used to study the pathophysiological mechanisms of pain as
studies in humans may be difficult to perform and ethically limited. As pain
cannot be directly measured in rodents, many methods that quantify "pain-like"
behaviors or nociception have been developed. These behavioral methods can be
divided into stimulus-evoked or non-stimulus evoked (spontaneous) nociception,
based on whether or not application of an external stimulus is used to elicit a
withdrawal response. Stimulus-evoked methods, which include manual and electronic
von Frey, Randall-Selitto and the Hargreaves test, were the first to be developed
and continue to be in widespread use. However, concerns over the clinical
translatability of stimulus-evoked nociception in recent years has led to the
development and increasing implementation of non-stimulus evoked methods, such as
grimace scales, burrowing, weight bearing and gait analysis. This review article
provides an overview, as well as discussion of the advantages and disadvantages
of the most commonly used behavioral methods of stimulus-evoked and
non-stimulus-evoked nociception used in rodents.