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2016 ; 73
(18
): 3453-72
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Methodologies in creating skin substitutes
#MMPMID27154041
Nicholas MN
; Jeschke MG
; Amini-Nik S
Cell Mol Life Sci
2016[Sep]; 73
(18
): 3453-72
PMID27154041
show ga
The creation of skin substitutes has significantly decreased morbidity and
mortality of skin wounds. Although there are still a number of disadvantages of
currently available skin substitutes, there has been a significant decline in
research advances over the past several years in improving these skin
substitutes. Clinically most skin substitutes used are acellular and do not use
growth factors to assist wound healing, key areas of potential in this field of
research. This article discusses the five necessary attributes of an ideal skin
substitute. It comprehensively discusses the three major basic components of
currently available skin substitutes: scaffold materials, growth factors, and
cells, comparing and contrasting what has been used so far. It then examines a
variety of techniques in how to incorporate these basic components together to
act as a guide for further research in the field to create cellular skin
substitutes with better clinical results.