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2016 ; 59
(8
): 3878-85
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Methamphetamine Vaccines: Improvement through Hapten Design
#MMPMID27054372
Collins KC
; Schlosburg JE
; Bremer PT
; Janda KD
J Med Chem
2016[Apr]; 59
(8
): 3878-85
PMID27054372
show ga
Methamphetamine (MA) addiction is a serious public health problem, and current
methods to abate addiction and relapse are currently ineffective for mitigating
this growing global epidemic. Development of a vaccine targeting MA would provide
a complementary strategy to existing behavioral therapies, but this has proven
challenging. Herein, we describe optimization of both hapten design and
formulation, identifying a vaccine that elicited a robust anti-MA immune response
in mice, decreasing methamphetamine-induced locomotor activity.