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10.1021/acs.jmedchem.6b00084

http://scihub22266oqcxt.onion/10.1021/acs.jmedchem.6b00084
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C5895457!5895457 !27054372
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suck abstract from ncbi


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pmid27054372
      J+Med+Chem 2016 ; 59 (8 ): 3878-85
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  • Methamphetamine Vaccines: Improvement through Hapten Design #MMPMID27054372
  • Collins KC ; Schlosburg JE ; Bremer PT ; Janda KD
  • J Med Chem 2016[Apr]; 59 (8 ): 3878-85 PMID27054372 show ga
  • Methamphetamine (MA) addiction is a serious public health problem, and current methods to abate addiction and relapse are currently ineffective for mitigating this growing global epidemic. Development of a vaccine targeting MA would provide a complementary strategy to existing behavioral therapies, but this has proven challenging. Herein, we describe optimization of both hapten design and formulation, identifying a vaccine that elicited a robust anti-MA immune response in mice, decreasing methamphetamine-induced locomotor activity.
  • |Animals [MESH]
  • |Antibody Formation [MESH]
  • |Enzyme-Linked Immunosorbent Assay [MESH]
  • |Haptens/*immunology [MESH]
  • |Locomotion/drug effects [MESH]
  • |Methamphetamine/*immunology/pharmacology [MESH]
  • |Mice [MESH]


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