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2016 ; 6
(3
): a025932
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Metformin: A Hopeful Promise in Aging Research
#MMPMID26931809
Novelle MG
; Ali A
; Diéguez C
; Bernier M
; de Cabo R
Cold Spring Harb Perspect Med
2016[Mar]; 6
(3
): a025932
PMID26931809
show ga
Even though the inevitable process of aging by itself cannot be considered a
disease, it is directly linked to life span and is the driving force behind all
age-related diseases. It is an undisputable fact that age-associated diseases are
among the leading causes of death in the world, primarily in industrialized
countries. During the last several years, an intensive search of antiaging
treatments has led to the discovery of a variety of drugs that promote health
span and/or life extension. The biguanide compound metformin is widely used for
treating people with type 2 diabetes and appears to show protection against
cancer, inflammation, and age-related pathologies. Here, we summarize the recent
developments about metformin use in translational aging research and discuss its
role as a potential geroprotector.