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10.18632/oncotarget.12859 http://scihub22266oqcxt.onion/10.18632/oncotarget.12859 C5346677!5346677 !27791206     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27791206 &cmd=llinks): Failed to open stream: HTTP request failed! 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Metformin treatment reduces temozolomide resistance of glioblastoma cells |pdf=|usr=}}{{27791206 }} gab.com Text Metformin treatment reduces temozolomide resistance of glioblastoma cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27791206 #FOAvip It has been reported that metformin acts synergistically with temozolomide (TMZ) to inhibit proliferation of glioma cells including glioblastoma multiforme (GBM). However, the molecular mechanism underlying how metformin exerts its anti-cancer effects remains elusive. We used a combined experimental and bioinformatics approach to identify genes and complex regulatory/signal transduction networks that are involved in restoring TMZ sensitivity of GBM cells after metformin treatment. First, we established TMZ resistant GBM cell lines and found that the resistant cells regained TMZ sensitivity after metformin treatment. We further identified that metformin down-regulates SOX2 expression in TMZ-resistant glioma cells, reduces neurosphere formation capacity of glioblastoma cells, and inhibits GBM xenograft growth in vivo. Finally, the global gene expression profiling data reveals that multiple pathways are involved in metformin treatment related gene expression changes, including fatty acid metabolism and RNA binding and splicing pathways. Our work provided insight of the mechanisms on potential synergistic effects of TMZ and metformin in the treatment of glioblastoma, which will in turn yield potentially translational value for clinical applications. Twit Text FOAVip Metformin treatment reduces temozolomide resistance of glioblastoma cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27791206 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27791206 #FOAvip English Wikipedia <ref>{{Cite pmid|27791206 }}</ref> Metformin treatment reduces temozolomide resistance of glioblastoma cells #MMPMID27791206 Yang SH ; Li S ; Lu G ; Xue H ; Kim DH ; Zhu JJ ; Liu Y Oncotarget 2016[Nov]; 7 (48 ): 78787-78803 PMID27791206 show ga It has been reported that metformin acts synergistically with temozolomide (TMZ) to inhibit proliferation of glioma cells including glioblastoma multiforme (GBM). However, the molecular mechanism underlying how metformin exerts its anti-cancer effects remains elusive. We used a combined experimental and bioinformatics approach to identify genes and complex regulatory/signal transduction networks that are involved in restoring TMZ sensitivity of GBM cells after metformin treatment. First, we established TMZ resistant GBM cell lines and found that the resistant cells regained TMZ sensitivity after metformin treatment. We further identified that metformin down-regulates SOX2 expression in TMZ-resistant glioma cells, reduces neurosphere formation capacity of glioblastoma cells, and inhibits GBM xenograft growth in vivo. Finally, the global gene expression profiling data reveals that multiple pathways are involved in metformin treatment related gene expression changes, including fatty acid metabolism and RNA binding and splicing pathways. Our work provided insight of the mechanisms on potential synergistic effects of TMZ and metformin in the treatment of glioblastoma, which will in turn yield potentially translational value for clinical applications. |*Drug Resistance, Neoplasm [MESH] |Animals [MESH] |Antineoplastic Combined Chemotherapy Protocols/*pharmacology [MESH] |Brain Neoplasms/*drug therapy/genetics/metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Cell Movement/*drug effects [MESH] |Cell Proliferation/*drug effects [MESH] |Dacarbazine/*analogs & derivatives/pharmacology [MESH] |Dose-Response Relationship, Drug [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Gene Regulatory Networks [MESH] |Glioblastoma/*drug therapy/genetics/metabolism/pathology [MESH] |Humans [MESH] |Inhibitory Concentration 50 [MESH] |Metformin/*pharmacology [MESH] |Mice, SCID [MESH] |Neoplasm Invasiveness [MESH] |SOXB1 Transcription Factors/genetics/metabolism [MESH] |Temozolomide [MESH] |Time Factors [MESH] |Transcriptome [MESH] |Tumor Burden/drug effects [MESH]Metformin treatment reduces temozolomide resistance of glioblastoma ce(epmc).pdf DeepDyve Pubget Overpricing