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2016 ; 529
(7586
): 298-306
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Metastatic colonization by circulating tumour cells
#MMPMID26791720
Massagué J
; Obenauf AC
Nature
2016[Jan]; 529
(7586
): 298-306
PMID26791720
show ga
Metastasis is the main cause of death in people with cancer. To colonize distant
organs, circulating tumour cells must overcome many obstacles through mechanisms
that we are only now starting to understand. These include infiltrating distant
tissue, evading immune defences, adapting to supportive niches, surviving as
latent tumour-initiating seeds and eventually breaking out to replace the host
tissue. They make metastasis a highly inefficient process. However, once
metastases have been established, current treatments frequently fail to provide
durable responses. An improved understanding of the mechanistic determinants of
such colonization is needed to better prevent and treat metastatic cancer.