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10.1038/nrc3910 http://scihub22266oqcxt.onion/10.1038/nrc3910 C4842412!4842412 !25801619     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25801619 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25801619 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Cancer 2015 ; 15 (4 ): 238-47 Nephropedia Template TP {{tp|p=25801619 |t=2015. Metastasis prevention by targeting the dormant niche |pdf=|usr=}}{{25801619 }} gab.com Text Metastasis prevention by targeting the dormant niche JO: Nat Rev Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25801619 #FOAvip Despite considerable advancements that shattered previously held dogmas about the metastatic cascade, the evolution of therapies to treat metastatic disease has not kept up. In this Opinion article, I argue that, rather than waiting for metastases to emerge before initiating treatment, it would be more effective to target metastatic seeds before they sprout. Specifically, I advocate directing therapies towards the niches that harbour dormant disseminated tumour cells to sensitize them to cytotoxic agents. Treatment sensitization, achieved by disrupting reservoirs of leukaemic stem cells and latent HIV, argues that this approach, although unconventional, could succeed in improving patient survival by delaying or even preventing metastasis. Twit Text FOAVip Metastasis prevention by targeting the dormant niche ????Nat Rev Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25801619 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25801619 #FOAvip English Wikipedia <ref>{{Cite pmid|25801619 }}</ref> Metastasis prevention by targeting the dormant niche #MMPMID25801619 Ghajar CM Nat Rev Cancer 2015[Apr]; 15 (4 ): 238-47 PMID25801619 show ga Despite considerable advancements that shattered previously held dogmas about the metastatic cascade, the evolution of therapies to treat metastatic disease has not kept up. In this Opinion article, I argue that, rather than waiting for metastases to emerge before initiating treatment, it would be more effective to target metastatic seeds before they sprout. Specifically, I advocate directing therapies towards the niches that harbour dormant disseminated tumour cells to sensitize them to cytotoxic agents. Treatment sensitization, achieved by disrupting reservoirs of leukaemic stem cells and latent HIV, argues that this approach, although unconventional, could succeed in improving patient survival by delaying or even preventing metastasis. |Animals [MESH] |Antineoplastic Agents/*therapeutic use [MESH] |Humans [MESH] |Neoplasm Metastasis/*prevention & control [MESH] |Neoplasms/*drug therapy/*pathology [MESH] |Stem Cell Niche/*drug effects [MESH]Metastasis prevention by targeting the dormant niche (epmc).pdf DeepDyve Pubget Overpricing