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Metalloproteinases: a Functional Pathway for Myeloid Cells
#MMPMID27227311
Chou J
; Chan MF
; Werb Z
Microbiol Spectr
2016[Apr]; 4
(2
): ? PMID27227311
show ga
Myeloid cells have diverse roles in regulating immunity, inflammation, and
extracellular matrix turnover. To accomplish these tasks, myeloid cells carry an
arsenal of metalloproteinases, which include the matrix metalloproteinases and
the adamalysins. These enzymes have diverse substrate repertoires, and are thus
involved in mediating proteolytic cascades, cell migration, and cell signaling.
Dysregulation of metalloproteinases contributes to pathogenic processes,
including inflammation, fibrosis, and cancer. Metalloproteinases also have
important nonproteolytic functions in controlling cytoskeletal dynamics during
macrophage fusion and enhancing transcription to promote antiviral immunity. This
review highlights the diverse contributions of metalloproteinases to myeloid cell
functions.
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