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2016 ; 9
(ä): 2429-36
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Metadherin regulates epithelial-mesenchymal transition in carcinoma
#MMPMID27143938
Wang Z
; Tang ZY
; Yin Z
; Wei YB
; Liu LF
; Yan B
; Zhou KQ
; Nian YQ
; Gao YL
; Yang JR
Onco Targets Ther
2016[]; 9
(ä): 2429-36
PMID27143938
show ga
Metadherin (MTDH) was first identified in primary human fetal astrocytes exposed
to HIV-1 in 2002 and then recognized as an important oncogene mediating
tumorigenesis, progression, invasiveness, and metastasis of carcinomas.
Epithelial-mesenchymal transition (EMT) is a vital process in embryonic
development, organ repair, and cancer progression. MTDH and EMT have also been
proved to be related to the prognosis of patients with cancers. Recent studies
reveal a relationship between MTDH overexpression and EMT in some malignancies.
This review highlights the overexpression of MTDH and EMT in cancers and their
correlations in clinical studies. Positive correlations have been established
between MTDH and mesenchymal biomarkers, and negative correlations between MTDH
and epithelial biomarkers have also been established. Furthermore, experiments
reveal EMT regulated by MTDH, and some signal pathways have been established.
Some anticancer drugs targeting MTDH and EMT are introduced in this review. Some
perspectives concerning EMT regulation by MTDH are also presented in this review.