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10.1158/0008-5472.CAN-16-0309 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-16-0309 C5093024!5093024 !27729325     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27729325 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Res 2016 ; 76 (21 ): 6146-6152 Nephropedia Template TP {{tp|p=27729325 |t=2016. Metabolite and Microbiome Interplay in Cancer Immunotherapy |pdf=|usr=}}{{27729325 }} gab.com Text Metabolite and Microbiome Interplay in Cancer Immunotherapy JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27729325 #FOAvip The role of the host microbiome has come to the forefront as a potential modulator of cancer metabolism and could be a future target for precision medicine. A recent study revealed that in colon cancer, bacteria form polysaccharide matrices called biofilms at a high frequency in the proximal colon. Comprehensive untargeted and stable isotope-assisted metabolomic analysis revealed that the bacteria utilize polyamine metabolites produced from colon adenomas/carcinomas to build these protective biofilms and may contribute to inflammation and proliferation observed in colon cancer. This study highlighted the importance of finding the biological origin of a metabolite and assessing its metabolism and mechanism of action. This led to a better understanding of host and microbial interactions, thereby aiding therapeutic design for cancer. In this review, we will discuss methodologies for identifying the biological origin and roles of metabolites in cancer progression and discuss the interactions of the microbiome and metabolites in immunity and cancer treatment, focusing on the flourishing field of cancer immunotherapy. Cancer Res; 76(21); 6146-52. ©2016 AACR. Twit Text FOAVip Metabolite and Microbiome Interplay in Cancer Immunotherapy ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27729325 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27729325 #FOAvip English Wikipedia <ref>{{Cite pmid|27729325 }}</ref> Metabolite and Microbiome Interplay in Cancer Immunotherapy #MMPMID27729325 Johnson CH ; Spilker ME ; Goetz L ; Peterson SN ; Siuzdak G Cancer Res 2016[Nov]; 76 (21 ): 6146-6152 PMID27729325 show ga The role of the host microbiome has come to the forefront as a potential modulator of cancer metabolism and could be a future target for precision medicine. A recent study revealed that in colon cancer, bacteria form polysaccharide matrices called biofilms at a high frequency in the proximal colon. Comprehensive untargeted and stable isotope-assisted metabolomic analysis revealed that the bacteria utilize polyamine metabolites produced from colon adenomas/carcinomas to build these protective biofilms and may contribute to inflammation and proliferation observed in colon cancer. This study highlighted the importance of finding the biological origin of a metabolite and assessing its metabolism and mechanism of action. This led to a better understanding of host and microbial interactions, thereby aiding therapeutic design for cancer. In this review, we will discuss methodologies for identifying the biological origin and roles of metabolites in cancer progression and discuss the interactions of the microbiome and metabolites in immunity and cancer treatment, focusing on the flourishing field of cancer immunotherapy. Cancer Res; 76(21); 6146-52. ©2016 AACR. |*Immunotherapy [MESH] |*Microbiota [MESH] |Bacteria/*metabolism [MESH] |Biofilms [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH]Metabolite and Microbiome Interplay in Cancer Immunotherapy (epmc).pdf DeepDyve Pubget Overpricing