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2017 ; 34
(9
): 2367-2379
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Metabolism and the Evolution of Social Behavior
#MMPMID28595344
Boyle KE
; Monaco HT
; Deforet M
; Yan J
; Wang Z
; Rhee K
; Xavier JB
Mol Biol Evol
2017[Sep]; 34
(9
): 2367-2379
PMID28595344
show ga
How does metabolism influence social behavior? This fundamental question at the
interface of molecular biology and social evolution is hard to address with
experiments in animals, and therefore, we turned to a simple microbial system:
swarming in the bacterium Pseudomonas aeruginosa. Using genetic engineering, we
excised a locus encoding a key metabolic regulator and disrupted P. aeruginosa's
metabolic prudence, the regulatory mechanism that controls expression of swarming
public goods and protects this social behavior from exploitation by cheaters.
Then, using experimental evolution, we followed the joint evolution of the
genome, the metabolome and the social behavior as swarming re-evolved. New
variants emerged spontaneously with mutations that reorganized the metabolome and
compensated in distinct ways for the disrupted metabolic prudence. These
experiments with a unicellular organism provide a detailed view of how
metabolism-currency of all physiological processes-can determine the costs and
benefits of a social behavior and ultimately influence how an organism behaves
towards other organisms of the same species.
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