Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26185076
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26185076
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Microbiol+Spectr
2015 ; 3
(3
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Metabolism and Fitness of Urinary Tract Pathogens
#MMPMID26185076
Alteri CJ
; Mobley HLT
Microbiol Spectr
2015[Jun]; 3
(3
): ä PMID26185076
show ga
Among common infections, urinary tract infections (UTI) are the most frequently
diagnosed urologic disease. The majority of UTIs are caused by uropathogenic
Escherichia coli. The primary niche occupied by E. coli is the lower intestinal
tract of mammals, where it resides as a beneficial component of the commensal
microbiota. Although it is well-known that E. coli resides in the human intestine
as a harmless commensal, specific strains or pathotypes have the potential to
cause a wide spectrum of intestinal and diarrheal diseases. In contrast,
extraintestinal E. coli pathotypes reside harmlessly in the human intestinal
microenvironment but, upon access to sites outside of the intestine, become a
major cause of human morbidity and mortality as a consequence of invasive UTI
(pyelonephritis, bacteremia, or septicemia). Thus, extraintestinal pathotypes
like uropathogenic E. coli (UPEC) possess an enhanced ability to cause infection
outside of the intestinal tract and colonize the urinary tract, the bloodstream,
or cerebrospinal fluid of human hosts. Due to the requirement for these E. coli
to replicate in and colonize both the intestine and extraintestinal environments,
we posit that physiology and metabolism of UPEC strains is paramount. Here we
discuss that the ability to survive in the urinary tract depends as much on
bacterial physiology and metabolism as it does on the well-considered virulence
determinants.
free
free
free
