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10.1097/MOL.0000000000000276 http://scihub22266oqcxt.onion/10.1097/MOL.0000000000000276 C5141383!5141383 !26825138     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26825138 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Curr+Opin+Lipidol 2016 ; 27 (2 ): 162-71 Nephropedia Template TP {{tp|p=26825138 |t=2016. Metabolic syndrome: genetic insights into disease pathogenesis |pdf=|usr=}}{{26825138 }} gab.com Text Metabolic syndrome: genetic insights into disease pathogenesis JO: Curr Opin Lipidol http://www.kidney.de/pget.php?&tw=1&pmid=26825138 #FOAvip PURPOSE OF REVIEW: Metabolic syndrome (MetS) is a cluster of interrelated and heritable metabolic traits, which collectively impart unsurpassed risk for atherosclerotic cardiovascular disease and type 2 diabetes. Considerable work has been done to understand the underlying disease mechanisms by elucidating its genetic cause. RECENT FINDINGS: Genome-wide association studies have been widely utilized albeit with modest success in identifying variants that are associated with more than two metabolic traits. Another limitation of this approach is the inherent small effect of the common variants, a major barrier for dissecting their cognate pathways. Modest advances in this venue have been also made by genetic studies of kindreds at the extreme ends of quantitative distributions. These efforts have led to the discovery of a number of disease genes with large effects that underlie the association of diverse traits of this syndrome. SUMMARY: Substantial progress has been made over the last decade in identification of genetic risk factors associated with the various traits of MetS. The heterogeneity and multifactorial heritability of MetS, however, has been a challenge toward understanding the factors underlying the association of these traits. Genetic investigations of outlier kindreds or homogenous populations with high prevalence for the disease can potentially improve our knowledge of the disease pathophysiology. Twit Text FOAVip Metabolic syndrome: genetic insights into disease pathogenesis ????Curr Opin Lipidol http://www.kidney.de/pget.php?&tw=1&pmid=26825138 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26825138 #FOAvip English Wikipedia <ref>{{Cite pmid|26825138 }}</ref> Metabolic syndrome: genetic insights into disease pathogenesis #MMPMID26825138 Abou Ziki MD ; Mani A Curr Opin Lipidol 2016[Apr]; 27 (2 ): 162-71 PMID26825138 show ga PURPOSE OF REVIEW: Metabolic syndrome (MetS) is a cluster of interrelated and heritable metabolic traits, which collectively impart unsurpassed risk for atherosclerotic cardiovascular disease and type 2 diabetes. Considerable work has been done to understand the underlying disease mechanisms by elucidating its genetic cause. RECENT FINDINGS: Genome-wide association studies have been widely utilized albeit with modest success in identifying variants that are associated with more than two metabolic traits. Another limitation of this approach is the inherent small effect of the common variants, a major barrier for dissecting their cognate pathways. Modest advances in this venue have been also made by genetic studies of kindreds at the extreme ends of quantitative distributions. These efforts have led to the discovery of a number of disease genes with large effects that underlie the association of diverse traits of this syndrome. SUMMARY: Substantial progress has been made over the last decade in identification of genetic risk factors associated with the various traits of MetS. The heterogeneity and multifactorial heritability of MetS, however, has been a challenge toward understanding the factors underlying the association of these traits. Genetic investigations of outlier kindreds or homogenous populations with high prevalence for the disease can potentially improve our knowledge of the disease pathophysiology. |Animals [MESH] |Genetic Linkage [MESH] |Genetic Predisposition to Disease [MESH] |Genome-Wide Association Study [MESH] |Humans [MESH]Metabolic syndrome: genetic insights into disease pathogenesis (epmc).pdf DeepDyve Pubget Overpricing