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2017 ; 6
(4
): 397-407
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Metabolic syndrome in children and adolescents
#MMPMID29184820
Al-Hamad D
; Raman V
Transl Pediatr
2017[Oct]; 6
(4
): 397-407
PMID29184820
show ga
Prevalence of metabolic syndrome in children and adolescents is increasing, in
parallel with the increasing trends in obesity rates. Varying definitions of this
syndrome have hindered the development of a consensus for the diagnostic criteria
in the pediatric population. While pathogenesis of metabolic syndrome is not
completely understood, insulin resistance and subsequent inflammation are thought
to be among its main mechanistic underpinnings. Overweight and obesity are
cardinal features, along with abnormal glucose metabolism, dyslipidemia, and
hypertension. Other disorders associated with metabolic syndrome include fatty
liver, polycystic ovarian syndrome (PCOS), and pro-inflammatory states.
Prevention and management of this condition can be accomplished with lifestyle
modifications, behavioral interventions, pharmacological and surgical
interventions as needed.