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2015 ; 51
(4
): 282-93
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Metabolic regulation via enzyme filamentation
#MMPMID27098510
Aughey GN
; Liu JL
Crit Rev Biochem Mol Biol
2015[Jul]; 51
(4
): 282-93
PMID27098510
show ga
Determining the mechanisms of enzymatic regulation is central to the study of
cellular metabolism. Regulation of enzyme activity via polymerization-mediated
strategies has been shown to be widespread, and plays a vital role in mediating
cellular homeostasis. In this review, we begin with an overview of the
filamentation of CTP synthase, which forms filamentous structures termed
cytoophidia. We then highlight other important examples of the phenomenon.
Moreover, we discuss recent data relating to the regulation of enzyme activity by
compartmentalization into cytoophidia. Finally, we hypothesize potential roles
for enzyme filament formation in the regulation of metabolism, development and
disease.