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2017 ; 13
(2
): 915
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Metabolic pattern formation in the tumor microenvironment
#MMPMID28183842
Dai Z
; Locasale JW
Mol Syst Biol
2017[Feb]; 13
(2
): 915
PMID28183842
show ga
Metabolic alterations including increased glycolysis are a common feature of many
cancers. In their recent study, Lowengrub, Waterman, and colleagues (Lee et al,
2017) report a spatial pattern of glycolysis in solid tumors that occurs within
the tumor microenvironment. This spatial organization is linked to gradients
derived from Wnt signaling and nutrient availability that mediate a
reaction?diffusion mechanism and is consistent with a Turing?type model of
spatial localization.