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2014 ; 15
(2
): 111-23
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Metabolic function of the CTRP family of hormones
#MMPMID23963681
Seldin MM
; Tan SY
; Wong GW
Rev Endocr Metab Disord
2014[Jun]; 15
(2
): 111-23
PMID23963681
show ga
Maintaining proper energy balance in mammals entails intimate crosstalk between
various tissues and organs. These inter-organ communications are mediated, to a
great extent, by secreted hormones that circulate in blood. Regulation of the
complex metabolic networks by secreted hormones (e.g., insulin, glucagon, leptin,
adiponectin, FGF21) constitutes an important mechanism governing the integrated
control of whole-body metabolism. Disruption of hormone-mediated metabolic
circuits frequently results in dysregulated energy metabolism and pathology. As
part of an effort to identify novel metabolic hormones, we recently characterized
a highly conserved family of 15 secreted proteins, the C1q/TNF-related proteins
(CTRP1-15). While related to adiponectin in sequence and structural organization,
each CTRP has its own unique tissue expression profile and non-redundant function
in regulating sugar and/or fat metabolism. Here, we summarize the current
understanding of the physiological functions of CTRPs, emphasizing their
metabolic roles. Future studies using gain-of-function and loss-of-function mouse
models will provide greater mechanistic insights into the critical role CTRPs
play in regulating systemic energy homeostasis.
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