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2016 ; 12
(5
): 299-308
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Metabolic effects of smoking cessation
#MMPMID26939981
Harris KK
; Zopey M
; Friedman TC
Nat Rev Endocrinol
2016[May]; 12
(5
): 299-308
PMID26939981
show ga
Smoking continues to be the leading cause of preventable death in the USA,
despite the vast and widely publicized knowledge about the negative health
effects of tobacco smoking. Data show that smoking cessation is often accompanied
by weight gain and an improvement in insulin sensitivity over time. However,
paradoxically, post-cessation-related obesity might contribute to insulin
resistance. Furthermore, post-cessation weight gain is reportedly the number one
reason why smokers, especially women, fail to initiate smoking cessation or
relapse after initiating smoking cessation. In this Review, we discuss the
metabolic effects of stopping smoking and highlight future considerations for
smoking cessation programs and therapies to be designed with an emphasis on
reducing post-cessation weight gain.