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2013 ; 465
(1
): 53-8
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Metabolic control of renin secretion
#MMPMID22729752
Peti-Peterdi J
; Gevorgyan H
; Lam L
; Riquier-Brison A
Pflugers Arch
2013[Jan]; 465
(1
): 53-8
PMID22729752
show ga
One emerging topic in renin-angiotensin system (RAS) research is the direct local
control of renin synthesis and release by endogenous metabolic intermediates.
During the past few years, our laboratory has characterized the localization and
signaling of the novel metabolic receptor GPR91 in the normal and diabetic kidney
and established GPR91 as a new, direct link between high glucose and RAS
activation in diabetes. GPR91 (also called SUCNR1) binds tricarboxylic acid (TCA)
cycle intermediate succinate which can rapidly accumulate in the local tissue
environment when energy supply and demand are out of balance. In a variety of
physiological and pathological conditions associated with metabolic stress,
succinate signaling via GPR91 appears to be an important mediator or modulator of
renin secretion. This review summarizes our current knowledge on the control of
renin release by molecules of endogenous metabolic pathways with the main focus
on succinate/GPR91.