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Baffi CW
; Wood L
; Winnica D
; Strollo PJ Jr
; Gladwin MT
; Que LG
; Holguin F
Chest
2016[Jun]; 149
(6
): 1525-34
PMID26836925
show ga
A link between metabolic syndrome (MetS) and lung diseases has been observed in
several cross-sectional and longitudinal studies. This syndrome has been
identified as an independent risk factor for worsening respiratory symptoms,
greater lung function impairment, pulmonary hypertension, and asthma. This review
will discuss several potential mechanisms to explain these associations,
including dietary factors and the effect of adiposity and fat-induced
inflammation on the lungs, and the role of other comorbidities that frequently
coexist with MetS, such as OSA and obesity. In contrast to the well-known
association between asthma and obesity, the recognition that MetS affects the
lung is relatively new. Although some controversy remains as to whether MetS is a
unique disease entity, its individual components have independently been
associated with changes in pulmonary function or lung disease. There is, however,
uncertainty as to the relative contribution that each metabolic factor has in
adversely affecting the respiratory system; also, it is unclear how much of the
MetS-related lung effects occur independently of obesity. In spite of these
epidemiological limitations, the proposed mechanistic pathways strongly suggest
that this association is likely to be causal. Given the wide prevalence of MetS
in the general population, it is imperative that we continue to further
understand how this metabolic disorder impacts the lung and how to prevent its
complications.
|*Lung Diseases/epidemiology/physiopathology/prevention & control
[MESH]
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free
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