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2017 ; 169
(4
): 570-586
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Metabolic Instruction of Immunity
#MMPMID28475890
Buck MD
; Sowell RT
; Kaech SM
; Pearce EL
Cell
2017[May]; 169
(4
): 570-586
PMID28475890
show ga
Choices have consequences. Immune cells survey and migrate throughout the body
and sometimes take residence in niche environments with distinct communities of
cells, extracellular matrix, and nutrients that may differ from those in which
they matured. Imbedded in immune cell physiology are metabolic pathways and
metabolites that not only provide energy and substrates for growth and survival,
but also instruct effector functions, differentiation, and gene expression. This
review of immunometabolism will reference the most recent literature to cover the
choices that environments impose on the metabolism and function of immune cells
and highlight their consequences during homeostasis and disease.