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2015 ; 6
(ä): 148
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Metabolic Effects of FGF-21: Thermoregulation and Beyond
#MMPMID26441838
Ni B
; Farrar JS
; Vaitkus JA
; Celi FS
Front Endocrinol (Lausanne)
2015[]; 6
(ä): 148
PMID26441838
show ga
Fibroblast growth factor (FGF)-21, a member of the FGF family, is a novel hormone
involved in the control of metabolism by modulating glucose homeostasis, insulin
sensitivity, ketogenesis, and promoting adipose tissue "browning." Recent studies
demonstrated that brown adipose tissue is not only a target for FGF-21, but is
also a potentially important source of systemic FGF-21. These findings support
the hypothesis that FGF-21 plays a physiologic role in thermogenesis and
thermogenic recruitment of white adipose tissue by an autocrine-paracrine axis.
This review examines the role of FGF-21 in thermogenesis from the perspective of
cell-based, animal model, and human studies. We also present recent advances in
the characterization of FGF-21's regulation of metabolism.