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2009 ; 2
(5
): 374-8
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English Wikipedia
Meta-analysis: A brief introduction
#MMPMID20443922
Andrel JA
; Keith SW
; Leiby BE
Clin Transl Sci
2009[Oct]; 2
(5
): 374-8
PMID20443922
show ga
Meta-analysis is the process of combining data from multiple sources and
analyzing it together to increase power and provide a clearer picture of the
effect of intervention or exposure on an outcome. The process is not complicated,
but requires a great deal of attention to detail. A specific set of inclusion
criteria for studies must be defined. Published or available study results may be
affected by publication bias of several different types, so the researcher should
be sure to conduct a thorough search of available databases in order to include
unpublished findings. Following selection, the group of studies should be
examined using funnel plots or statistical tests. Meta-analysis models themselves
must be selected to properly reflect the combined studies. Both fixed- and
random-effects modeling are discussed. Two case studies are presented,
illustrating a well-conducted meta-analysis and a meta-analysis that was more
controversial.