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2015 ; 45
(Pt A
): 139-45
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Meta-analysis in clinical trials revisited
#MMPMID26343745
DerSimonian R
; Laird N
Contemp Clin Trials
2015[Nov]; 45
(Pt A
): 139-45
PMID26343745
show ga
In this paper, we revisit a 1986 article we published in this Journal,
Meta-Analysis in Clinical Trials, where we introduced a random-effects model to
summarize the evidence about treatment efficacy from a number of related clinical
trials. Because of its simplicity and ease of implementation, our approach has
been widely used (with more than 12,000 citations to date) and the "DerSimonian
and Laird method" is now often referred to as the 'standard approach' or a
'popular' method for meta-analysis in medical and clinical research. The method
is especially useful for providing an overall effect estimate and for
characterizing the heterogeneity of effects across a series of studies. Here, we
review the background that led to the original 1986 article, briefly describe the
random-effects approach for meta-analysis, explore its use in various settings
and trends over time and recommend a refinement to the method using a robust
variance estimator for testing overall effect. We conclude with a discussion of
repurposing the method for Big Data meta-analysis and Genome Wide Association
Studies for studying the importance of genetic variants in complex diseases.
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