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2015 ; 6
(ä): 113
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Mesothelial cells in tissue repair and fibrosis
#MMPMID26106328
Mutsaers SE
; Birnie K
; Lansley S
; Herrick SE
; Lim CB
; Prêle CM
Front Pharmacol
2015[]; 6
(ä): 113
PMID26106328
show ga
Mesothelial cells are fundamental to the maintenance of serosal integrity and
homeostasis and play a critical role in normal serosal repair following injury.
However, when normal repair mechanisms breakdown, mesothelial cells take on a
profibrotic role, secreting inflammatory, and profibrotic mediators,
differentiating and migrating into the injured tissues where they contribute to
fibrogenesis. The development of new molecular and cell tracking techniques has
made it possible to examine the origin of fibrotic cells within damaged tissues
and to elucidate the roles they play in inflammation and fibrosis. In addition to
secreting proinflammatory mediators and contributing to both coagulation and
fibrinolysis, mesothelial cells undergo mesothelial-to-mesenchymal transition, a
process analogous to epithelial-to-mesenchymal transition, and become fibrogenic
cells. Fibrogenic mesothelial cells have now been identified in tissues where
they have not previously been thought to occur, such as within the parenchyma of
the fibrotic lung. These findings show a direct role for mesothelial cells in
fibrogenesis and open therapeutic strategies to prevent or reverse the fibrotic
process.
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