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10.1097/COC.0b013e318210f83c http://scihub22266oqcxt.onion/10.1097/COC.0b013e318210f83c C3121923!3121923 !21422993     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\21422993 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Clin+Oncol 2013 ; 36 (3 ): 299-309 Nephropedia Template TP {{tp|p=21422993 |t=2013. Merkel cell carcinoma |pdf=|usr=}}{{21422993 }} gab.com Text Merkel cell carcinoma JO: Am J Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=21422993 #FOAvip Merkel cell carcinoma (MCC) is a rare, clinically aggressive cutaneous neuroendocrine neoplasm with a high mortality rate. Though the etiology is not precisely known, Merkel cell polyomavirus DNA has been found recently in a large percentage of MCC tumors. Other suggested risk factors include sun exposure, immunosuppression, and a history of prior malignancy. Work up of patients with MCC most notably includes nodal staging via clinical examination or sentinel lymph node biopsy. The prognosis for most patients with MCC is poor, and the rarity of MCC precludes the prospective, randomized clinical trials necessary to elucidate optimum treatment protocols. Most published data support the use of a multimodality approach centered around surgical excision with negative margins, sentinel lymph node biopsy to establish the presence or absence of nodal metastases, adjuvant radiothearpy to decrease the risk of recurrence, and systemic chemotherapy in the case of widespread disease. Twit Text FOAVip Merkel cell carcinoma ????Am J Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=21422993 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21422993 #FOAvip English Wikipedia <ref>{{Cite pmid|21422993 }}</ref> Merkel cell carcinoma #MMPMID21422993 Ramahi E ; Choi J ; Fuller CD ; Eng TY Am J Clin Oncol 2013[Jun]; 36 (3 ): 299-309 PMID21422993 show ga Merkel cell carcinoma (MCC) is a rare, clinically aggressive cutaneous neuroendocrine neoplasm with a high mortality rate. Though the etiology is not precisely known, Merkel cell polyomavirus DNA has been found recently in a large percentage of MCC tumors. Other suggested risk factors include sun exposure, immunosuppression, and a history of prior malignancy. Work up of patients with MCC most notably includes nodal staging via clinical examination or sentinel lymph node biopsy. The prognosis for most patients with MCC is poor, and the rarity of MCC precludes the prospective, randomized clinical trials necessary to elucidate optimum treatment protocols. Most published data support the use of a multimodality approach centered around surgical excision with negative margins, sentinel lymph node biopsy to establish the presence or absence of nodal metastases, adjuvant radiothearpy to decrease the risk of recurrence, and systemic chemotherapy in the case of widespread disease. |Carcinoma, Merkel Cell/diagnosis/*therapy [MESH] |Combined Modality Therapy [MESH] |Humans [MESH] |Prognosis [MESH]Merkel cell carcinoma (epmc).pdf DeepDyve Pubget Overpricing