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2015 ; 2015
(ä): 402381
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Meningococcal B Vaccination (4CMenB) in Infants and Toddlers
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Esposito S
; Tagliabue C
; Bosis S
J Immunol Res
2015[]; 2015
(ä): 402381
PMID26351647
show ga
Neisseria meningitidis is a Gram-negative pathogen that actively invades its
human host and leads to the development of life-threatening pathologies. One of
the leading causes of death in the world, N. meningitidis can be responsible for
nearly 1,000 new infections per 100,000 subjects during an epidemic period. The
bacterial species are classified into 12 serogroups, five of which (A, B, C, W,
and Y) cause the majority of meningitides. The three purified protein conjugate
vaccines currently available target serogroups A, C, W, and Y. Serogroup B has
long been a challenge but the discovery of the complete genome sequence of an
MenB strain has allowed the development of a specific four-component vaccine
(4CMenB). This review describes the pathogenetic role of N. meningitidis and the
recent literature concerning the new meningococcal vaccine.
|*Vaccination
[MESH]
|Age Factors
[MESH]
|Child, Preschool
[MESH]
|Humans
[MESH]
|Infant
[MESH]
|Infant, Newborn
[MESH]
|Meningitis, Meningococcal/*immunology/*prevention & control
[MESH]