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2015 ; 348
(6238
): 1007-13
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Memory Engram cells retain memory under retrograde amnesia
#MMPMID26023136
Ryan TJ
; Roy DS
; Pignatelli M
; Arons A
; Tonegawa S
Science
2015[May]; 348
(6238
): 1007-13
PMID26023136
show ga
Memory consolidation is the process by which a newly formed and unstable memory
transforms into a stable long-term memory. It is unknown whether the process of
memory consolidation occurs exclusively through the stabilization of memory
engrams. By using learning-dependent cell labeling, we identified an increase of
synaptic strength and dendritic spine density specifically in consolidated memory
engram cells. Although these properties are lacking in engram cells under protein
synthesis inhibitor-induced amnesia, direct optogenetic activation of these cells
results in memory retrieval, and this correlates with retained engram
cell-specific connectivity. We propose that a specific pattern of connectivity of
engram cells may be crucial for memory information storage and that strengthened
synapses in these cells critically contribute to the memory retrieval process.
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