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2014 ; 1
(3
): 137-146
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Memory T Cells in Transplantation
#MMPMID25435071
Su CA
; Fairchild RL
Curr Transplant Rep
2014[Sep]; 1
(3
): 137-146
PMID25435071
show ga
Following infections and environmental exposures, memory T cells are generated
that provide long-term protective immunity. Compared to their naïve T cell
counterparts, memory T cells possess unique characteristics that endow them with
the ability to quickly and robustly respond to foreign antigens. While such
memory T cells are beneficial in protecting their hosts from recurrent infection,
memory cells reactive to donor antigens pose a major barrier to successful
transplantation and tolerance induction. Significant progress has been made over
the past several decades contributing to our understanding of memory T cell
generation, their distinct biology, and their detrimental impact in clinical and
animal models of transplantation. This review focuses on the unique features
which make memory T cells relevant to the transplant community and discusses
potential therapies targeting memory T cells which may ameliorate allograft
rejection.