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10.1007/s40472-014-0018-5

http://scihub22266oqcxt.onion/10.1007/s40472-014-0018-5
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suck abstract from ncbi


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pmid25435071
      Curr+Transplant+Rep 2014 ; 1 (3 ): 137-146
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  • Memory T Cells in Transplantation #MMPMID25435071
  • Su CA ; Fairchild RL
  • Curr Transplant Rep 2014[Sep]; 1 (3 ): 137-146 PMID25435071 show ga
  • Following infections and environmental exposures, memory T cells are generated that provide long-term protective immunity. Compared to their naïve T cell counterparts, memory T cells possess unique characteristics that endow them with the ability to quickly and robustly respond to foreign antigens. While such memory T cells are beneficial in protecting their hosts from recurrent infection, memory cells reactive to donor antigens pose a major barrier to successful transplantation and tolerance induction. Significant progress has been made over the past several decades contributing to our understanding of memory T cell generation, their distinct biology, and their detrimental impact in clinical and animal models of transplantation. This review focuses on the unique features which make memory T cells relevant to the transplant community and discusses potential therapies targeting memory T cells which may ameliorate allograft rejection.
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