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10.1681/ASN.2015111262 http://scihub22266oqcxt.onion/10.1681/ASN.2015111262 C5328151!5328151 !27756808     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27756808 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Am+Soc+Nephrol 2017 ; 28 (3 ): 995-1003 Nephropedia Template TP {{tp|p=27756808 |t=2017. Membranous Nephropathy: Quantifying Remission Duration on Outcome |pdf=|usr=}}{{27756808 }} gab.com Text Membranous Nephropathy: Quantifying Remission Duration on Outcome JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=27756808 #FOAvip Although change in proteinuria has been proposed as a surrogate for long-term prognosis in membranous nephropathy (MGN), variability in proteinuria levels and lag between these changes and acceptable end points, such as ESRD, has limited its utility. This cohort study examined the prognostic significance of remission duration in 376 patients with biopsy-proven idiopathic/primary MGN who achieved a remission after a period of nephrotic-range proteinuria. We defined complete remission (CR), partial remission (PR), and relapse as proteinuria ?0.3, 0.4-3.4, and ?3.5 g/d after CR or PR, respectively. The exposure variable was the remission status of patients at fixed landmarks (3, 6, 12, 24, and 36 months) after the date of first remission. The primary outcome was ESRD or 50% reduction in eGFR. We fitted Cox proportional hazards models to examine the association of remission status at each landmark and the primary end point. Persistent remission associated with unadjusted hazard ratios for the primary outcome that ranged by landmark from 0.35 (95% confidence interval, 0.20 to 0.61) to 0.56 (95% confidence interval, 0.31 to 1.04). Separate analyses for PR and CR yielded similar results. After adjustment, maintaining remission associated with significantly reduced risk of the primary outcome at all landmarks. Durable remissions associated with improved renal survival. Although the longer the remission, the greater the improvement, patients with remission durations as short as 3 months had improved renal prognosis compared with patients who relapsed. This study validates and quantifies PR and CR as surrogates for long-term outcome in MGN. Twit Text FOAVip Membranous Nephropathy: Quantifying Remission Duration on Outcome ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=27756808 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27756808 #FOAvip English Wikipedia <ref>{{Cite pmid|27756808 }}</ref> Membranous Nephropathy: Quantifying Remission Duration on Outcome #MMPMID27756808 Cattran DC ; Kim ED ; Reich H ; Hladunewich M ; Kim SJ J Am Soc Nephrol 2017[Mar]; 28 (3 ): 995-1003 PMID27756808 show ga Although change in proteinuria has been proposed as a surrogate for long-term prognosis in membranous nephropathy (MGN), variability in proteinuria levels and lag between these changes and acceptable end points, such as ESRD, has limited its utility. This cohort study examined the prognostic significance of remission duration in 376 patients with biopsy-proven idiopathic/primary MGN who achieved a remission after a period of nephrotic-range proteinuria. We defined complete remission (CR), partial remission (PR), and relapse as proteinuria ?0.3, 0.4-3.4, and ?3.5 g/d after CR or PR, respectively. The exposure variable was the remission status of patients at fixed landmarks (3, 6, 12, 24, and 36 months) after the date of first remission. The primary outcome was ESRD or 50% reduction in eGFR. We fitted Cox proportional hazards models to examine the association of remission status at each landmark and the primary end point. Persistent remission associated with unadjusted hazard ratios for the primary outcome that ranged by landmark from 0.35 (95% confidence interval, 0.20 to 0.61) to 0.56 (95% confidence interval, 0.31 to 1.04). Separate analyses for PR and CR yielded similar results. After adjustment, maintaining remission associated with significantly reduced risk of the primary outcome at all landmarks. Durable remissions associated with improved renal survival. Although the longer the remission, the greater the improvement, patients with remission durations as short as 3 months had improved renal prognosis compared with patients who relapsed. This study validates and quantifies PR and CR as surrogates for long-term outcome in MGN. |Cohort Studies [MESH] |Female [MESH] |Glomerulonephritis, Membranous/complications/*therapy [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Prognosis [MESH] |Proteinuria/etiology/therapy [MESH] |Remission Induction [MESH] |Time Factors [MESH]Membranous Nephropathy: Quantifying Remission Duration on Outcome (epmc).pdf DeepDyve Pubget Overpricing