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10.1053/j.ajkd.2016.01.030 http://scihub22266oqcxt.onion/10.1053/j.ajkd.2016.01.030 C4921260!4921260 !27085376     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27085376 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Kidney+Dis 2016 ; 68 (1 ): 138-47 Nephropedia Template TP {{tp|p=27085376 |t=2016. Membranous Nephropathy: A Journey From Bench to Bedside |pdf=|usr=}}{{27085376 }} gab.com Text Membranous Nephropathy: A Journey From Bench to Bedside JO: Am J Kidney Dis http://www.kidney.de/pget.php?&tw=1&pmid=27085376 #FOAvip Lessons from an animal model that faithfully resembles human membranous nephropathy (MN) have informed our understanding of the pathogenesis of this organ-specific autoimmune disease and common cause of nephrotic syndrome. After it was established that the subepithelial immune deposits that characterize experimental MN form in situ when circulating antibodies bind to an intrinsic podocyte antigen, it was merely a matter of time before the human antigen was identified. The M-type phospholipase A2 receptor 1 (PLA2R) represents the major target antigen in primary MN, and thrombospondin type 1 domain-containing 7A (THSD7A) was more recently identified as a minor antigen. Serologic tests for anti-PLA2R and kidney biopsy specimen staining for PLA2R show >90% specificity and 70% to 80% sensitivity for the diagnosis of primary MN in most populations. The assays distinguish most cases of primary MN from MN associated with other systemic diseases, and sequential anti-PLA2R titers are useful to monitor treatment response. A positive pretransplantation test result for anti-PLA2R is also helpful for predicting the risk for posttransplantation recurrence. Identification of target epitopes within PLA2R and the genetic association of primary MN with class II major histocompatibility and PLA2R1 variants are 2 additional examples of our evolving understanding of this disease. Twit Text FOAVip Membranous Nephropathy: A Journey From Bench to Bedside ????Am J Kidney Dis http://www.kidney.de/pget.php?&tw=1&pmid=27085376 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27085376 #FOAvip English Wikipedia <ref>{{Cite pmid|27085376 }}</ref> Membranous Nephropathy: A Journey From Bench to Bedside #MMPMID27085376 Francis JM ; Beck LH Jr ; Salant DJ Am J Kidney Dis 2016[Jul]; 68 (1 ): 138-47 PMID27085376 show ga Lessons from an animal model that faithfully resembles human membranous nephropathy (MN) have informed our understanding of the pathogenesis of this organ-specific autoimmune disease and common cause of nephrotic syndrome. After it was established that the subepithelial immune deposits that characterize experimental MN form in situ when circulating antibodies bind to an intrinsic podocyte antigen, it was merely a matter of time before the human antigen was identified. The M-type phospholipase A2 receptor 1 (PLA2R) represents the major target antigen in primary MN, and thrombospondin type 1 domain-containing 7A (THSD7A) was more recently identified as a minor antigen. Serologic tests for anti-PLA2R and kidney biopsy specimen staining for PLA2R show >90% specificity and 70% to 80% sensitivity for the diagnosis of primary MN in most populations. The assays distinguish most cases of primary MN from MN associated with other systemic diseases, and sequential anti-PLA2R titers are useful to monitor treatment response. A positive pretransplantation test result for anti-PLA2R is also helpful for predicting the risk for posttransplantation recurrence. Identification of target epitopes within PLA2R and the genetic association of primary MN with class II major histocompatibility and PLA2R1 variants are 2 additional examples of our evolving understanding of this disease. |*Glomerulonephritis, Membranous/blood/genetics/immunology [MESH] |Autoantibodies/analysis [MESH] |Biomedical Research [MESH] |Humans [MESH] |Kidney/chemistry/immunology [MESH] |Prognosis [MESH] |Receptors, Phospholipase A2/immunology [MESH]Membranous Nephropathy: A Journey From Bench to Bedside (epmc).pdf DeepDyve Pubget Overpricing