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2013 ; 82
(ä): 663-92
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Membrane fission reactions of the mammalian ESCRT pathway
#MMPMID23527693
McCullough J
; Colf LA
; Sundquist WI
Annu Rev Biochem
2013[]; 82
(ä): 663-92
PMID23527693
show ga
The endosomal sorting complexes required for transport (ESCRT) pathway was
initially defined in yeast genetic screens that identified the factors necessary
to sort membrane proteins into intraluminal endosomal vesicles. Subsequent
studies have revealed that the mammalian ESCRT pathway also functions in a series
of other key cellular processes, including formation of extracellular
microvesicles, enveloped virus budding, and the abscission stage of cytokinesis.
The core ESCRT machinery comprises Bro1 family proteins and ESCRT-I, ESCRT-II,
ESCRT-III, and VPS4 complexes. Site-specific adaptors recruit these soluble
factors to assemble on different cellular membranes, where they carry out
membrane fission reactions. ESCRT-III proteins form filaments that draw membranes
together from the cytoplasmic face, and mechanistic models have been advanced to
explain how ESCRT-III filaments and the VPS4 ATPase can work together to catalyze
membrane fission.
|Animals
[MESH]
|Cell Membrane/*metabolism
[MESH]
|Endosomal Sorting Complexes Required for Transport/chemistry/*metabolism
[MESH]