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2016 ; 26
(3
): 146-60
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Membrane dynamics associated with viral infection
#MMPMID26817660
de Armas-Rillo L
; Valera MS
; Marrero-Hernández S
; Valenzuela-Fernández A
Rev Med Virol
2016[May]; 26
(3
): 146-60
PMID26817660
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Viral replication and spreading are fundamental events in the viral life cycle,
accounting for the assembly and egression of nascent virions, events that are
directly associated with viral pathogenesis in target hosts. These processes
occur in cellular compartments that are modified by specialized viral proteins,
causing a rearrangement of different cell membranes in infected cells and
affecting the ER, mitochondria, Golgi apparatus, vesicles and endosomes, as well
as processes such as autophagic membrane flux. In fact, the activation or
inhibition of membrane trafficking and other related activities are fundamental
to ensure the adequate replication and spreading of certain viruses. In this
review, data will be presented that support the key role of membrane dynamics in
the viral cycle, especially in terms of the assembly, egression and infection
processes. By defining how viruses orchestrate these events it will be possible
to understand how they successfully complete their route of infection,
establishing viral pathogenesis and provoking disease.
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