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2016 ; 4
(ä): 35
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Membrane Tethering Complexes in the Endosomal System
#MMPMID27243003
Spang A
Front Cell Dev Biol
2016[]; 4
(ä): 35
PMID27243003
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Vesicles that are generated by endocytic events at the plasma membrane are
destined to early endosomes. A prerequisite for proper fusion is the tethering of
two membrane entities. Tethering of vesicles to early endosomes is mediated by
the class C core vacuole/endosome tethering (CORVET) complex, while fusion of
late endosomes with lysosomes depends on the homotypic fusion and vacuole protein
sorting (HOPS) complex. Recycling through the trans-Golgi network (TGN) and to
the plasma membrane is facilitated by the Golgi associated retrograde protein
(GARP) and endosome-associated recycling protein (EARP) complexes, respectively.
However, there are other tethering functions in the endosomal system as there are
multiple pathways through which proteins can be delivered from endosomes to
either the TGN or the plasma membrane. Furthermore, proteins that may be part of
novel tethering complexes have been recently identified. Thus, it is likely that
more tethering factors exist. In this review, I will provide an overview of
different tethering complexes of the endosomal system and discuss how they may
provide specificity in membrane traffic.
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