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2014 ; 12
(12
): 1487-99
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Melioidosis: molecular aspects of pathogenesis
#MMPMID25312349
Stone JK
; DeShazer D
; Brett PJ
; Burtnick MN
Expert Rev Anti Infect Ther
2014[Dec]; 12
(12
): 1487-99
PMID25312349
show ga
Burkholderia pseudomallei is a gram-negative bacterium that causes melioidosis, a
multifaceted disease that is highly endemic in southeast Asia and northern
Australia. This facultative intracellular pathogen possesses a large genome that
encodes a wide array of virulence factors that promote survival in vivo by
manipulating host cell processes and disarming elements of the host immune
system. Antigens and systems that play key roles in B. pseudomallei virulence
include capsular polysaccharide, lipopolysaccharide, adhesins, specialized
secretion systems, actin-based motility and various secreted factors. This review
provides an overview of the current and steadily expanding knowledge regarding
the molecular mechanisms used by this organism to survive within a host and their
contribution to the pathogenesis of melioidosis.