Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20008709
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20008709
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Arch+Ophthalmol
2009 ; 127
(12
): 1572-80
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Melanoma-associated retinopathy: a paraneoplastic autoimmune complication
#MMPMID20008709
Lu Y
; Jia L
; He S
; Hurley MC
; Leys MJ
; Jayasundera T
; Heckenlively JR
Arch Ophthalmol
2009[Dec]; 127
(12
): 1572-80
PMID20008709
show ga
OBJECTIVES: To study 11 patients with melanoma-associated retinopathy (MAR) to
clarify the reliability of various methods of diagnostic testing, to determine
the underlying antigenic retinal proteins, and to study the clinical histories
and types of associated melanomas. METHODS: Clinical data were obtained from
patients with melanoma who developed marked visual problems. Testing included
electroretinography, kinetic visual fields, comparative studies of Western blots,
and indirect immunohistologic examination to detect antiretinal antibodies, as
well as proteomic studies to identify underlying antigenic retinal proteins.
RESULTS: Patients with MAR typically have rapid onset of photopsias, scotomata,
and loss of central or paracentral vision. Ophthalmoscopy seldom shows
significant changes early, but electroretinograms are abnormal. Results of
Western blots and immunohistologic examination can show antiretinal antibodies
but not always. Most patients (9 of 11) had a strong family history of autoimmune
disorders. Any type of melanoma (cutaneous, choroidal, ciliary body, or choroidal
nevi) may be associated with this paraneoplastic autoimmune reactivity. MAR may
precede or follow the diagnosis of melanoma. Patients with MAR have the same
antigenic retinal proteins that have been associated with cancer-associated
retinopathy. In addition, 2 new antigenic retinal proteins, aldolase A and
aldolase C, were found. CONCLUSIONS: There was a high prevalence of positive
family histories of autoimmune disease in patients with MAR. To confirm the
disorder, multiple clinical and serum diagnostic techniques (Western blot or
indirect immunohistologic examination) are needed. Two newly observed antigenic
retinal proteins, aldolase A and aldolase C, are associated with MAR.
free
free
free
